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Dawood, Nausheen
- Antioxidant Activity of Geraniol on n-Nitrosodiethylamine-induced Hepatocarcinogenesis in Wistar Albino Rats
Abstract Views :442 |
PDF Views:290
Authors
Affiliations
1 Department of Biochemistry, JBAS College for Women, Chennai, IN
2 Prof. Dhanapalan College of Arts and Science, Chennai, IN
3 PNG University of Technology, IN
4 CLRI, Chennai, IN
1 Department of Biochemistry, JBAS College for Women, Chennai, IN
2 Prof. Dhanapalan College of Arts and Science, Chennai, IN
3 PNG University of Technology, IN
4 CLRI, Chennai, IN
Source
Indian Journal of Oncology and Radiation Biology, Vol 2, No 7 (2014), Pagination: 4-9Abstract
The chemopreventive effect of Geraniol was evaluated in N-nitrosodiethylamine-induced experimental liver tumor in Wistar albino rats. In this study the animals were divided into four groups with 6 rats each and received treatments for 4 weeks. Group I served as control (untreated), Group II treated with N-nitrosodiethylamine (DEN) (200 mgkg, i.p.) and Phenobarbital (PB) (0.05%) in drinking water; Group III received Geraniol (250 mg/kg b.wt) in addition to DEN and Group IV treated with Geraniol only for four weeks. The administration of Geraniol in rats with DEN induced HCC rats (Group III) shows a significantly reduced level of liver serum marker (aspartate aminotransferase, alanine aminotransferase, acid phosphatase, alkaline phosphatase, lactate dehydrogenase, gammaglutamyl transpeptidase, alpha fetoprotein and 5'nucleotidase). These results are evident that Geraniol possesses protective effect against N-Nitrosodiethylamine (DEN)-induced Hepatocellular Carcinogenesis (HCC).Keywords
DEN, Carcinogenesis, HCC, Geraniol, Marker Enzymes- Microbial Dynamics of Endemic Earthworms on Soil Health and Sustainable Agriculture
Abstract Views :179 |
PDF Views:0
Authors
Affiliations
1 P.G. and Research Department of Zoology, JBAS College for Women, Chennai-600018, T. N., IN
2 Ecoscience Research Foundation, Chennai-600 041, T. N., IN
1 P.G. and Research Department of Zoology, JBAS College for Women, Chennai-600018, T. N., IN
2 Ecoscience Research Foundation, Chennai-600 041, T. N., IN